Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain

Table 2 Effects of allopurinol or exogenous glutathione on various gastric parameters in sham operation and BCAL rats

	mg/kg	Acid back-diffusion (μEq/stomach)	Glutathione (μmol/g tissue)	Lipid peroxide (nmol MDA/g tissue)	Histamine (μg/g tissue)	Hemoglobin (mg/stomach)	Erosion area (mm2)
Sham operation
Vehicle		-135.4 ± 4.4	2.8 ± 0.3	50.1 ± 4.5	56.1 ± 5.4	0.5 ± 0.2	2.4 ± 3.5
Allopurinol	100	-112.0 ± 3.8a	3.0 ± 0.3	40.2 ± 4.7a	40.5 ± 5.1a	0.2 ± 0.1a	0.2 ± 0.2a
Glutathione	800	-98.0 ± 2.4a	3.4 ± 0.2a	36.1 ± 2.5a	38.1 ± 4.6a	0.1 ± 0.1a	0.4 ± 0.2a
BCAL
Vehicle		-250.2 ± 14.4	1.4 ± 0.2	128.0 ± 9.3	120.4 ± 9.8	2.3 ± 0.3	45.2 ± 6.1
Allopurinol	100	-181.5 ± 5.8c	2.2 ± 0.2c	68.4 ± 5.1c	77.3 ± 6.9c	1.2 ± 0.2c	20.3 ± 2.9c
Glutathione	800	-146.0 ± 3.4c	2.7 ± 0.2c	56.1 ± 4.5c	80.1 ± 4.6c	0.1 ±  0.1c	12.4 ± 3.5c

Data are means±SE (N = 6).

^aP <  0.05 vs sham operative vehicle.

^cP <  0.05 vs BCAL vehicle. MDA= malonedialdehyde, BCAL= bilateral carotid artery ligation.