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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 21, 2006; 12(39): 6343-6348
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6343
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6343
Table 3 Allele and genotype frequencies of UGT1A7 and UGT1A9 gene polymorphisms in pancreatic cancers and controls n (%)
| Polymorphisms | Cases (n = 61) | Controls(n = 105) |
| UGT1A7 (exon 1) | ||
| Allele frequencies | ||
| *1 | 54 (44.3) | 74 (35.0) |
| *2 | 15 (12.3) | 46 (22.0) |
| *3 | 52 (42.6) | 89 (42.0) |
| *4 | 1 (0.8) | 1 (1.0) |
| CLUMP (T1): χ2 = 5.66 (df = 3), P = 0.10 | ||
| CLUMP (T3-column used 2): χ2 = 4.75 (df = 1), Pc = 0.07 (uncorrected P = 0.03) | ||
| Genotype frequencies | ||
| *1*1 | 10 (16.4) | 14 (13.3) |
| *1*2 | 7 (11.5) | 12 (11.4) |
| *2*2 | 2 (3.3) | 6 (5.7) |
| *1*3 | 26 (42.6) | 34 (32.4) |
| *2*3 | 4 (6.6) | 22 (21.0) |
| *3*3 | 11 (18.0) | 16 (15.2) |
| *1*4 | 1 (1.6) | 0 (0.0) |
| *3*4 | 0 (0.0) | 1 (1.0) |
| CLUMP (T1): χ2 = 9.43 (df = 9), P = 0.21 | ||
| CLUMP (T3-column used 5): χ2 = 6.05 (df = 1), Pc = 0.07 (uncorrected P = 0.01) | ||
| UGT1A9 (exon 1) | ||
| Allele frequencies | ||
| *1 | 121 (99.2) | 206 (98.0) |
| *5 | 1 (0.8) | 2 (1.0) |
| *4 | 0 (0.0) | 2 (1.0) |
| CLUMP (T1): χ2 = 1.19 (df = 2), P = 0.79 | ||
| Genotype frequencies | ||
| *1*1 | 60 (98.4) | 101 (96.2) |
| *1*5 | 1 (1.6) | 2 (1.9) |
| *1*4 | 0 (0.0) | 2 (1.9) |
| CLUMP (T1): χ2 = 1.19 (df = 5), P = 0.79 | ||
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Citation: Piepoli A, Gentile A, Valvano MR, Barana D, Oliani C, Cotugno R, Quitadamo M, Andriulli A, Perri F. Lack of association between
UGT1A7, UGT1A9, ARP, SPINK1 andCFTR gene polymorphisms and pancreatic cancer in Italian patients. World J Gastroenterol 2006; 12(39): 6343-6348 - URL: https://www.wjgnet.com/1007-9327/full/v12/i39/6343.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i39.6343