Cytoplasmic expression of p27kip1 is associated with a favourable prognosis in colorectal cancer patients

Table 3 Multivariate analysis of Cytoplasmic p27^kip expression in relation to known clinical and pathological variables (n = 418)

Variable	Category	Hazardratio(HR)	95% CIfor HR	P
Gender	Female	1
	Male	1.055	0.787-1.415	0.719
Patient age (yr)	< 65	1
	65-79	1.262	0.843-1.889
	80+	1.609	0.961-2.694	0.194
Tumor site	Colon	1
	Rectal	1.117	0.813-1.535
	Unknown	1.452	0.870-2.423	0.353
Tumor histological type	Adenocarcinoma	1
	Non-adenocarcinoma	0.956	0.621-1.472	0.838
Tumor grade	Well differentiated	1
	Moderately differentiated	1.167	0.582-2.337
	Poorly differentiated	1.139	0.528-2.457
	Unknown	0.869	0.245-3.079	0.926
Vascular invasion	Negative	1
	Positive	1.884	1.344-2.641
	Unknown	1.308	0.876-1.954	0.001
Tumor (TNM) stage	0/I	1
	II	2.021	1.102-3.708
	III	3.741	2.066-6.774
	IV	16.977	8.829-32.645
	Unknown	4.211	1.049-16.902	< 0.001
Cytoplasmic p27Kip1 expression	Negative	1
	Positive	0.681	0.458-1.015	0.059