Resistance to activated protein C is a risk factor for fibrostenosis in Crohn’s disease

Table 2 Intestinal CD-related surgery in 32 patients with Crohn's disease (frequencies, %, median values)

	With aPCR	Without aPCR
	(n = 8)	(n = 24)
Patients having undergone an operation1	6 (75%)	16 (67%)
Patients having undergone an operation with fibrostenosis2	6 (75%)	13 (54%)
Patients with fibrostenosis at 1st operation2	6/6 (100%)	10/16 (62.5%)
Location of fibrostenosis at 1st operation3
Terminal ileum	4	8
Colon	2	0
Upper gastrointestinal tract	0	2
Median time from diagnosis of CD to 1st operation1 (mo)	32	80.5
Median time from diagnosis of CD to 1st operation with fibrostenosis2 (mo)	32a	160

aPCR: resistance to activated protein C; CD: Crohn’s disease.

¹Operations:intestinal CD-related operations;

²Operations with fibrostenosis: intestinal CD-related operations with fibrostenosis;

³The location of fibrostenosis was classified according to the Vienna classification for location of Crohn’s disease[26].

^aP < 0.05 vs patients without aPCR.