Probiotics and prebiotics in chronic inflammatory bowel diseases

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Oct 7, 2006 (publication date) through Jul 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2006; 12(37): 5941-5950
Published online Oct 7, 2006. doi: 10.3748/wjg.v12.i37.5941

Table 2 Clinical studies of prebiotics in IBD

Author	Design	Group (Dose/d) (n)		Results
Author	Design	Probiotic	Comparator
Induction of remission of ulcerative colitis
Kanauchi 2003 [112]	Open label	Conventional therapy + Germinated barley foodstuff (20-30 g) (21)	Conventional therapy	Results	Improved UCDAI
Furrie 2005 [114]	DB, R, C	B. longum (2 × 10¹¹) + inulin/oligofructose (6 g) (9)	Placebo (9)	Sigmoidoscopy scores reduced (P = 0.06) β-defensins, TNFα , IL-1α levels decreased (P < 0.05)
Maintenance of remission of ulcerative colitis
Hanai 2004 [113]	Open label	Conventional therapy + Germinated barley foodstuff (20 g) (22)	Conventional therapy (37)	Improved UCDAI and endoscopic scores
Induction of remission of Crohn’s disease
Lindsay 2006 [115]	Open label	Fructo-oligosaccharides (15 g) (10)	None	Increase in IL-10 expressing intestinal dendritic cells

Citation: Ewaschuk JB, Dieleman LA. Probiotics and prebiotics in chronic inflammatory bowel diseases. World J Gastroenterol 2006; 12(37): 5941-5950
URL: https://www.wjgnet.com/1007-9327/full/v12/i37/5941.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i37.5941