Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas

Table 1 False negative in antigen positive neoplasms,comparative features of microsatellite unstable sporadic adenocarcinoma and hnpcc colon carcinomas

	MSI-H sporadic adenocarcinomas	HNPCC adenocarcinomas
Patient age	Older	Younger
Number of tumors	Single	Single/Multiple (synchronic/metachronic)
Colonic distribution	Right colon	Right colon
Histological clues	Poorly differentiated, medullary type Crohn-like inflammation	Poorly differentiated, medullary type Crohn-like inflammation
Mechanism of MMR deficiency	MLH1 promoter hypermethylation	Inactivating germline mutation of MMR proteins
Tumor prognosis	Better than MSI-L/MSS sporadic adenoca	Better than MSI-L/MSS sporadic adenoca