The epidemiology of hyperferritinaemia

Table 1 Conditions associated with raised ferritin and diagnostic criteria used

Condition	Requirements for diagnosis
Hereditary haemochromatosis	Genotyped and / or biopsy proven
Renal failure	Dialysis dependent
Alcoholic liver disease (ALD)	Liver biopsy or Liver Function Test (LFT) abnormality compatible with ALD in patients with history of alcohol excess (> 30 u/wk) in whom other causes have been excluded
Inflammatory disease	Raised C-Reactive Protein (CRP) and/or Erythrocyte Sedimentation Rate (ESR) on more than one consecutive test and recognised active inflammatory disease
Repeated blood transfusion	More than 4 unit packed cell transfusion in preceding 6 mo
Autoimmune disease	Recognised autoimmune disease with positive auto-antibody test
Other liver disease	All other recognised causes of parenchymal liver damage with abnormal LFTs, excluding ALD and HHC
Haematological disease	Bone marrow or blood film proven primary haematological disorder
Neoplasia	Histologically proven neoplastic disease
Weight loss	More than 10% body mass (kg) lost in preceding six months
Human immuno-deficiency virus (HIV)	Positive HIV test