Non-surgical treatment of esophageal achalasia

Table 4 Effect of BoTx on esophageal achalasia (only studies with at least 30 patients are reported)

Authors	Toxin units	n	% LES decrease	Response 1 mo (%)	Response 6 mo (%)	Response 12 mo (%)
Pasricha, 1996	80	31	45	90	55	-
Fishman, 1996	100	60	-	88	-	46
Cuilliere, 1997	80	56	31	75	60	-
Annese, 1998	100	57	55	88	55	35
Prakash, 1999	80	42	-	90	64	41
Kolbasnik, 1999	100	30	28	77	37	29
Annese, 1999	100-250	78	42	86	61	-
Annese, 2000	Variable	118	34	82	53	-
D’Onofrio, 2002	100	37	-	84	-	67
Storr, 2002	100	40	-	-	68	-
Martinek, 2003	100-250	49	65	93	-	41
Zaninotto, 2004	100	40	-	-	66	34