Gastric atrophy, diagnosing and staging

Table 1 The diagnosis of pseudopyloric metaplasia can be facilitated by using pepsinogen I immunostain

	PepsinogenI (PGI)	Pepsinogen II (PG II)
Chief cells	Positive	Positive
Mucous neck cells	Positive	Positive
Antral gland cells	Negative	Positive

PepsinogenI(PGI) is localized in chief cells, mucous-neck cells and transitional mucous-neck/chief cells of the human fundic mucosa[78]; it is not localized in antral gland cells. Pepsinogen II, on the other hand is localized in chief cells, mucous neck cells, and antral gland cells.