Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer

Figure 4 Additive growth inhibition by NVP-AEW541 plus fluvastatin (mean ± SE, n = 3-5). Fluvastatin (1-50 μmol/L) induced a dose-dependent growth inhibition of HCT-116 (A) and HT-29 (B) cells by > 80% when applied for 3 d. Moreover, combination treatment with sub-IC₅₀ concentrations of fluvastatin and NVP-AEW541 led to (over-)additive growth inhibition after 3 d of treatment. Black bars indicate the values of the calculated additive growth inhibition.