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World J Gastroenterol. Sep 21, 2006; 12(35): 5687-5691
Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5687
Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5687
Table 2 Expression of Hedgehog pathway components in various categories of intestinal stromal tumors n (%)
Shh | Ptc | Smo | Gli-1 | ||||||
n | + | - | + | - | + | - | + | - | |
GIST | 31 | 18 (58.1) | 13 (41.9) | 24 (77.4) | 7 (22.6) | 25 (80.6) | 6 (19.4) | 18 (58.1) | 13 (41.9) |
Risk categories | P < 0.05 | NS | NS | NS | |||||
High | 4 | 1 (25.0) | 3 (75.0) | 3 (75.0) | 1 (25.0) | 3 (75.0) | 1 (25.0) | 3 (75.0) | 1 (25.0) |
Intermediate | 6 | 3 (50.0) | 3 (50.0) | 5 (83.3) | 1 (16.7) | 4 (66.7) | 2 (33.3) | 2 (33.3) | 4 (66.7) |
Low | 16 | 9 (56.3) | 7 (43.8) | 11 (68.8) | 5 (31.3) | 13 (81.3) | 3 (18.8) | 9 (56.3) | 7 (43.8) |
Very low | 5 | 5 (100) | 0 (0.0) | 5 (100) | 0 (0.0) | 5 (100) | 0 (0.0) | 4 (80.0) | 1 (20.0) |
Tumor size (cm in diameter) | P < 0.05 | NS | NS | NS | |||||
n ≤ 2 | 8 | 7 (87.5) | 1 (12.5) | 7 (87.5) | 1 (12.5) | 8 (100) | 0 (0.0) | 6 (75.0) | 2 (25.0) |
2 < n ≤ 5 | 18 | 10 (55.6) | 8 (44.4) | 14 (77.8) | 4 (22.2) | 13 (72.2) | 5 (27.8) | 8 (44.4) | 10 (55.6) |
5 < n | 5 | 1 (20.0) | 4 (80.0) | 3 (60.0) | 2 (40.0) | 4 (80.0) | 1 (20.0) | 4 (80.0) | 1 (20.0) |
Mitosis counts1 | NS | NS | NS | NS | |||||
0-5 | 23 | 13 (56.5) | 10 (43.5) | 17 (73.9) | 6 (26.1) | 18 (78.3) | 5 (21.7) | 14 (60.9) | 9 (39.1) |
6-10 | 3 | 2 (66.7) | 1 (33.3) | 3 (100) | 0 (0.0) | 3 (100) | 0 (0.0) | 2 (66.7) | 1 (33.3) |
11-28 | 5 | 3 (60.0) | 2 (40.0) | 4 (80.0) | 1 (20.0) | 4 (80.0) | 1 (20.0) | 2 (40.0) | 3 (60.0) |
- Citation: Yoshizaki A, Nakayama T, Naito S, Wen CY, Sekine I. Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis. World J Gastroenterol 2006; 12(35): 5687-5691
- URL: https://www.wjgnet.com/1007-9327/full/v12/i35/5687.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i35.5687