Occurrence of cGMP/nitric oxide-sensitive store-operated calcium entry in fibroblasts and its effect on matrix metalloproteinase secretion

Figure 2 Inhibitory effect of Ni²⁺ on thapsigargin-induced rise in [Ca²⁺]_i. The cells were incubated in NPBS with 4 μmol/L thapsigargin and 3 mmol/L NiCl₂ for 90 s, then the media were replaced with respective media containing 2 mmol/L CaCl₂ without EGTA, no significant change of [Ca²⁺]_i occurred after 120 s.