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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 14, 2006; 12(34): 5517-5522
Published online Sep 14, 2006. doi: 10.3748/wjg.v12.i34.5517
Published online Sep 14, 2006. doi: 10.3748/wjg.v12.i34.5517
Table 2 Expression of leptin and clinicopathologic characteristics of patients
Leptin expression | OB-R expression | |||||
High (74) | Low (133) | P | Positive (67) | Negative (140) | P | |
Age (yr) | 62.7 ± 8.9 | 61.3 ± 11.2 | 0.98 | 64.2 ± 9.9 | 61.6 ± 10.8 | 0.167 |
Sex | ||||||
Male | 64 | 91 | 53 | 102 | ||
Female | 10 | 42 | 0.003 | 14 | 38 | 0.33 |
BMI | 22.4 ± 3.1 | 22.7 ± 2.8 | 0.48 | 22.4 ± 3.2 | 22.7 ± 2.8 | 0.49 |
Tumor markers | ||||||
CEA | 8.6 ± 17.7 | 14.7 ± 111.3 | 0.65 | 9.9 ± 19.6 | 13.8 ± 108.3 | 0.79 |
CA19-9 | 89.8 ± 453.5 | 75.4 ± 347.6 | 0.81 | 138.3 ± 561.4 | 53.8 ± 270.8 | 0.16 |
Size (cm) | 6.0 ± 3.2 | 5.1 ± 3.6 | 0.13 | 5.8 ± 3.2 | 5.2 ± 3.6 | 0.25 |
Location | ||||||
Upper part (51) | 23 | 28 | 19 | 32 | ||
Middle part (94) | 36 | 58 | 29 | 65 | ||
Lower part (62) | 15 | 47 | 0.03 | 19 | 43 | 0.51 |
Depth of tumor invasion | ||||||
T1 | 24 | 76 | 20 | 80 | ||
T2 | 28 | 29 | 27 | 37 | ||
T3 | 18 | 28 | 16 | 30 | ||
T4 | 4 | 0 | 0.001 | 4 | 0 | < 0.001 |
Macroscopic type | ||||||
Elevated | 57 | 62 | 48 | 71 | ||
Depressed/flat | 17 | 71 | < 0.001 | 19 | 69 | 0.005 |
Histological type | ||||||
Differentiated | 45 | 43 | 43 | 45 | ||
Undifferentiated | 29 | 90 | < 0.001 | 24 | 95 | < 0.001 |
TNM stage | ||||||
IA | 20 | 67 | 15 | 72 | ||
IB | 17 | 23 | 15 | 25 | ||
II | 8 | 12 | 9 | 11 | ||
IIIA | 10 | 17 | 11 | 16 | ||
IIIB | 5 | 7 | 7 | 5 | ||
IV | 14 | 7 | 0.001 | 10 | 11 | < 0.001 |
Lymphatic invasion | ||||||
Positive | 39 | 45 | 39 | 46 | ||
Negative | 34 | 87 | 0.002 | 28 | 94 | < 0.001 |
Venous invasion | ||||||
Positive | 46 | 49 | 45 | 50 | ||
Negative | 28 | 84 | < 0.001 | 22 | 90 | < 0.001 |
Lymph node metastasis | ||||||
Positive | 47 | 48 | 48 | 47 | ||
Negative | 37 | 85 | 0.052 | 19 | 93 | 0.001 |
Hematogenous metastasis | ||||||
Positive | 3 | 0 | 2 | 1 | ||
Negative | 71 | 134 | 0.02 | 65 | 139 | 0.19 |
Peritoneal dissemination | ||||||
Positive | 5 | 1 | 2 | 4 | ||
Negative | 69 | 133 | 0.01 | 65 | 136 | 0.95 |
- Citation: Ishikawa M, Kitayama J, Nagawa H. Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer. World J Gastroenterol 2006; 12(34): 5517-5522
- URL: https://www.wjgnet.com/1007-9327/full/v12/i34/5517.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i34.5517