-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

doi:10.3748/wjg.v12.i34.5473

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Sep 14, 2006 (publication date) through Feb 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Sep 14, 2006; 12(34): 5473-5478
Published online Sep 14, 2006. doi: 10.3748/wjg.v12.i34.5473

Table 3 Frequency distributions and Odds Ratio for risk of atrophy and intestinal metaplasia or gastric adenocarcinoma in -765 C carriers

Pathology	Genotype n (%)		OR (95% CI)		OR²(95% Cl)
Pathology	GG	C carrier			OR²(95% Cl)
Controls	130 (62)	80 (38)	OR (95% CI)		1.00 (Reference)	1.00 (Reference)¹
Atrophy or intestinal metaplasia	27 (73)	10 (27)	0.60 (0.28-1.31)	0.95 (0.91-0.99)¹	1.00 (Reference)
Gastric adenocarcinoma	36 (49)	37 (51)	1.67 (0.98-2.86)	1.45 (0.84-2.64)¹	2.67 (1.03-6.93)

¹ OR adjusted for age and gender in a multivariate logistic regression analysis;

² OR adjusted for age and gender in a multivariate logistic regression analysis for the progression of atrophy or intestinal metaplasia into gastric cancer.

Citation: Pereira C, Sousa H, Ferreira P, Fragoso M, Moreira-Dias L, Lopes C, Medeiros R, Dinis-Ribeiro M. -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia. World J Gastroenterol 2006; 12(34): 5473-5478
URL: https://www.wjgnet.com/1007-9327/full/v12/i34/5473.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i34.5473