Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets

Figure 5 Effects of taurolithocholate (TLC) on the contraction interval of bile canaliculi. The histogram of the canalicular contraction interval revealed Poisson distribution. In the TLC-treated groups, there was a tendency for the peak height to decrease and shift to the right. The calculated theoretical peak values for each dose were 4.7 min in the control groups (A), 5.7 min at 10 μmol/L TLC (B) and 7.0 min at 50 μmol/L (C). Normalized errors are indicated in parentheses.