Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa™) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects

Figure 3 p-Akt and p-Erk1/2 modulation after prolonged exposure to gefitinib or ZD6474. Cells were incubated with gefitinib or ZD6474 for 7 and 14 d with continuous and intermittent exposure. Drug-dependent p-Akt and p-Erk1/2 modulation was determined by Western blotting. All data are shown relative to the baseline level (control = 0), which was similar after 7 and 14 d.