Effect of Fructus Psoraleae on motility of gallbladder isolated smooth muscle strips from guinea pigs

Table 3 Effect of Fructus Psoraleae on the contractile frequency(waves/min) of isolated gallbladder muscle strip after pretreated with antagonists (means ± SD)

Frequency (w/min)	Fructus psoraleae (g/L)
	0	0.1	0.3	1	3	10	20
Pso	3.3 ± 0.5	3.3 ± 0.7	3.3 ± 0.6	3.8 ± 0.9	4.6 ± 0.7b	7.3 ± 1.2d	8.3 ± 1.2d
Ben + Pso	3.4 ± 0.5	3.6 ± 0.4	3.6 ± 0.4	3.7 ± 0.4	4.6 ± 0.4d	6.3 ± 0.5d	7.3 ± 0.8d
Phe + Pso	3.5 ± 0.7	3.9 ± 0.8	3.9 ± 0.8	4.4 ± 1.0	5.1 ± 0.8b	7.1 ± 1.2d	9.1 ± 1.1d
4-DAMP + Pso	3.5 ± 0.4	3.5 ± 0.4	3.6 ± 0.6	3.9 ± 0.7	4.2 ± 0.5a	5.1 ± 0.9dh	6.8 ± 0.5df
Hex + Pso	3.3 ± 0.5	3.5 ± 0.8	3.5 ± 0.5	3.9 ± 0.8	4.8 ± 1.0d	6.0 ± 0.7cd	7.0 ± 0.9cd
Ido + Pso	3.4 ± 0.5	3.4 ± 0.6	3.6 ± 0.7	3.8 ± 0.7	4.4 ± 0.7a	6.9 ± 1.4d	8.4 ± 1.1d
Iso + Pso	3.4 ± 0.5	3.4 ± 0.8	3.5 ± 0.8	3.8 ± 0.9	5.2 ± 1.4b	6.3 ± 1.2d	8.8 ± 1.6d

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs control (under 1-g initial load the gallbladder spontaneous contraction frequency when Fructus Psoraleae was 0 g/L ) (n = 8).

^cP < 0.05,

^fP < 0.01,

^hP < 0.001 vs Fructus Psoraleae (contraction frequency of adding each concentration of Fructus Psoraleae) (n = 8).