Eradication of H pylori for the prevention of gastric cancer

Table 1 Gastric cancer prevention studies

Study	Design	Follow-up	Patients	Treatment	Outcome
Uemura et al 1997	Nonrandomized intervention trial	2 yr	132 Japanese patients with endoscopically removed early stage gastric cancer and H pylori infection	H pylori eradication therapy or no treatment	Reduced rate of gastric cancer development after eradication of H pylori
Saito et al 2000	Nonrandomized intervention trial	2 yr	64 Japanese patients with gastric adenoma and Hpylori infection	H pylori eradication therapy or no treatment	Reduced rate of metachronous gastric cancer development after eradication of H pylori
Correa et al 2000	Prospective, randomized, placebo controlled trial	6 yr	852 individuals from a high risk region in Colombia with H pylori infection and precancerous lesions	H pylori eradication therapy and/or ascorbic acid/beta-carotene or placebo	Significant increase in the rate of regression of precursor conditions after cure of H pylori and/or treatment with dietary supplements
Wong et al 2004	Prospective, randomized, placebo controlled trial	8 yr	1630 individuals from a high risk region in China with H pylori infection; with or without precancerous lesions	H pylori eradication therapy or placebo	Significant reduction in gastric cancer risk after cure of H pylori only for patients without precancerous conditions
Take et al 2005	Nonrandomized intervention trial	3.4 yr	1342 Japanese patients with peptic ulcer disease	H pylori eradication therapy	Significant increase in gastric cancer risk for patients with persistent H pylori infection