Administration of granulocyte colony stimulating factor after liver transplantation leads to an increased incidence and severity of ischemic biliary lesions in the rat model

Table 3 Signs of a hypercoaguable state after G-CSF treatment in healthy volunteers and in patients with G-CSF producing tumors

Author	n	Observations after G-CSF administration or in patients with G-CSF producing tumors
Topcuoglu et al, 2004[9]	18	Stimulation of thrombotic factors and increased endothelial markers, such as FVIII and vWF
		No clinical silent microembolism detected by transcranial Doppler
Sohngen et al, 1998[13]	25	Hypercoaguable state
LeBlanc et al, 1999[10]	22	Increased levels of FVIIIC and thrombin
		Reduced platelet aggregation.
Kuroiwa et al, 1996[12]	10	Significant increase of platelet aggregation induced by ADP or collagen, thromboxane B2 level and amount of thrombin-antithrombin III complex.
Canales et al, 2002[32]	20	Significant increase in F1 + 2 and D-dimer
		Significant decrease of antithrombin and protein C activity
		Significant increase of vWF
		Slightly significant decrease of angiotensin converting enzyme
Suzuki et al, 1992[33]	14	Thrombocytosis