Gene expression analysis of primary normal human hepatocytes infected with human hepatitis B virus

Table 1 Forty-five differentially down-regulated genes obtained and categorized by their function

Categoty	UniGene	Gene nam	Symbol	Locus	Function	Control/HBV infection	P-value
Transcription/ RNA Pol II	Hs.442675	Thyroid hormone receptor interactor 8	TRIP8	10	Transcription co-activator of Pol II promoter	3.469	0.030
Transcription	Hs.57475	Sex comb on midleg homolog 1	SCMH1	1p34	Pol II transcription	3.315	0.019
Transcription	Hs.119014	Zinc finger protein 175	ZNF175	19q13.4	C2H2 zinc-finger protein 175	2.942	0.017
Transcription/ RNA Pol II	Hs.437905	Spi-B transcription factor (Spi-1/PU.1 related)	SPIB	19q13.3-q13.4	RNA polymerase II transcription factor	2.743	0.017
Transcription/ RNA Pol II	Hs.148427	LIM homeobox protein 3	LHX3	9q34.3	RNA Pol 2 transcription factor and activate pituitary hormone genes	2.492	0.006
Signal	Hs.17154	Dual-specificity tyrosine-(Y)- phosphorylation regulated kinase 4	DYRK4	12p13.32	Dual-specificity protein kinase 4	3.938	0.005
Signal	Hs.262886	Inositol polyphosphate-5- phosphatase, 145kD	INPP5D	2q36-q37	Modulating cytokine signaling within the hemopoietic system	3.587	0.009
Signal	Hs.75249	ADP-ribosylation factor-like 6 interacting protein	ARL6IP	16p12-p11.2	Activator of phospholipase D (PLD)	2.801	0.010
Tumor/Suppress	Hs.77793	c-src tyrosine kinase	CSK	15q23-q25	Downregulate the tyrosine kinase activity of the c-src oncoprotein	3.377	0.021
Tumor/Induce	Hs.89839	EphA1	EPHA1	7q34	Overexpression of EPH mRNA was found in a hepatoma	3.039	0.022
Tumor/Induce	Hs.79070	V-myc avian myelocytomatosis viral oncogene homolog	MYC	8q24.12-q24.13	Promotes cell proliferation and transformation	2.357	0.011
Immune response	Hs.118354	Human MHC Class I region proline rich protein mRNA	CAT56	6p21.32	Immune response	2.588	0.024
Miscellaneous	Hs.180610	Splicing factor proline/ glutamine rich	SFPQ	1p34.3	Pre-mRNA splicing factor required for pre-mRNA splicing	10.471	0.006
Miscellaneous/ Cytoskeleton	Hs.75064	Tubulin-specific chaperone c	TBCC	6pter-p12.1	Cofactor in the folding pathway of beta-tubulin	10.2	0.020
Miscellaneous	Hs.438683	BCM-like membrane protein precursor	SBB142	1q23.1	BCM-like membrane protein precursor	3.751	0.004
Miscellaneous	Hs.8203	Endomembrane protein emp70 precursor isolog	LOC56889	10q24.2	Low similarity to human endosomal protein P76	3.502	0.038
Miscellaneous	Hs.311609	Nuclear RNA helicase, DECD variant of DEAD box family	DDXL	19p13.13	Member of the DEAD/H box ATP- dependent RNA helicase family	2.868	0.026
Miscellaneous/ Energy	Hs.150922	BCS1 (yeast homolog)-like	BCS1L	2q33	Function in the assembly of complex III of the respiratory chain	2.682	0.007
Miscellaneous	Hs.6679	hHDC for homolog of Drosophila headcase	LOC51696	6q23-q24	hHDC for homolog of Drosophila headcase	2.611	0.020
Miscellaneous	Hs.5300	Bladder cancer associated protein	BLCAP	20q11.2-q12	Appears to be down-regulated during bladder cancer progression	2.459	0.028
Miscellaneous	Hs.179526	Upregulated by 1, 25-dihydroxyvitamin D-3	VDUP1	1q21.2	Upregulated by 1, 25-dihydroxyvitamin D-3	2.394	0.043
Miscellaneous	Hs.440961	Calpastatin	CAST	5q15-q21	Inhibitor of the cysteine (thiol) protease calpain	2.276	0.000
Miscellaneous	Hs.275775	Selenoprotein P, plasma, 1	SEPP1	5q31	An oxidant defense in the extracellular space	2.186	0.007
EST	Hs.371233	ESTs		Xp22.3	Moderately similar to T08795 hypothetical protein DKFZp586J1822.1	7.826	0.025
EST	Hs.229338	ESTs		X		4.687	0.007
EST	Hs.212957	ESTs		3q26.1	Moderately similar to ZN91_HUMAN ZINC FINGER PROTEIN 91	4.611	0.019
EST	Hs.211823	ESTs		2q37.1		4.519	0.030
EST	Hs.57836	ESTs		17		3.323	0.029
EST	Hs.87912	ESTs		14q24.1		3.314	0.013
EST	Hs.12429	ESTs	FLJ22479	4q26-q27	Hypothetical protein FLJ22479	3.217	0.041
EST	Hs.213586	ESTs		7		2.759	0.044
EST	Hs.2755711	ESTs		22	Weakly similar to T20379 hypothetical protein	2.723	0.019
EST	Hs.191435	ESTs		8p23.1-p22	Weakly similar to S65657 alpha-1C- adrenergic receptor splice form 2	2.638	0.023
EST	Hs.31293	ESTs		9p13.1		2.286	0.035
Predicted protein	Hs.414464	Hypothetical protein	HSD3.1	14q31.3		7.314	0.008
Predicted protein	Hs.100914	Hypothetical protein FLJ10352	FLJ10352	18p11.21		6.239	0.006
Predicted protein	Hs.181112	HSPC126 protein	HSPC126	13q14.12		3.322	0.045
Predicted protein	Hs.306711	KIAA1081 protein	ELKS	12p13.3		3.122	0.036
Predicted protein	Hs.101891	KIAA1193 protein	KIAA1193	19p13.3	Weakly similar to RPB1_HUMAN DNA-directed RNA Pol II largest subunit	3.029	0.030
Predicted protein	Hs.272759	KIAA1457 protein	KIAA1457	12q24.31		2.98	0.020
Predicted protein	Hs.172089	Homo sapiens mRNA; cDNA DKFZp586I2022		11q22.1		2.784	0.036
Predicted protein	Hs.7049	Hypothetical protein FLJ11305	FLJ11305	13q34		2.65	0.028
Predicted protein	Hs.445255	KIAA0368 protein	KIAA0368	9q32		2.423	0.016
Predicted protein	Hs.192190	KIAA0782 protein	KIAA0782	11q13.3		2.332	0.009
Predicted protein	Hs.169910	KIAA0173 gene product	KIAA0173	2p24.3-p24.1	Similar to S72482 hypothetical protein	2.171	0.014