Insights on augmenter of liver regeneration cloning and function

doi:10.3748/wjg.v12.i31.4951

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Aug 21, 2006 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2006; 12(31): 4951-4958
Published online Aug 21, 2006. doi: 10.3748/wjg.v12.i31.4951

Table 1 Augmenter of liver regeneration from yeast to man

	Homo Sapiens (Human)	Mus Musculus (Mouse)	Rattus Norvegicus (Rat)	Saccharomyces cerevisae (Yeast)
Description	Augmenter of liver regeneration (ALR)/growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) (GFER)/ hepatic regenerative stimulation substance (HSS)/hepatopoietin (HPO)	Augmenter of liver regeneration (Alr)/growth factor, erv1 (S. cerevisiae)- like (augmenter of liver regeneration) (Gfer)	Augmenter of liver regeneration (ALR)/ growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) (Gfer)	Saccharomyces cerevisiae ERV1 (scERV1)/flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space, has a role in the maturation of cytosolic iron-sulphur proteins; ortholog of human hepatopoietin (ALR)
Genomic Location	Chromosome: 16 Cytogenetic: 16p13.3-p13.12	Chromosome: 17 Cytogenetic: 17 A3.3	Chromosome: 10 Cytogenetic: 10q12 Genetic: 17 10.0 cM	Chromosome: VII
Peptide Length	205 aa (23 ku) 125 aa (15 ku)	198 aa	125 aa (15 ku)	189 aa (22 ku)
Protein Function	In liver regeneration and spermatogenesis	In liver regeneration and spermatogenesis	In liver regeneration and spermatogenesis	Essential for the biogenesis of mitochondria, cell viability and for vegetative growth
Protein Subunit	Homodimer/Heterodimer	Homodimer	Homodimer	Homodimer
Protein Similarity	Belongs to ERV1/ALR family	Belongs to ERV1/ALR family	Belongs to ERV1/ALR family	Belongs to ERV1/ALR family
Percentage of similarity to human		85.6% [The comparison with human is based on nucleic acid (GeneCard for GFER)] 87.20% [The comparison with human is based on amino acid sequence (UniGene)]	85.87% [The comparison with human is based on nucleic acid (GeneCard for GFER)] 85.60% [The comparison with human is based on amino acid sequence (UniGene)]	52.85% [The comparison with human is based on nucleic acid (GeneCard for GFER)] 46.85% [The comparison with human is based on amino acid sequence (UniGene)]
Subcellular Location	Nucleus (15 ku) Cytosol (23 ku) Mitochondrial intermembrane space (23 ku)	Mitochondrial intermembrane space	Cytosol Mitochondrial intermembrane space	Cytosol Mitochondrial intermembrane space

Citation: Gatzidou E, Kouraklis G, Theocharis S. Insights on augmenter of liver regeneration cloning and function. World J Gastroenterol 2006; 12(31): 4951-4958
URL: https://www.wjgnet.com/1007-9327/full/v12/i31/4951.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i31.4951