Hereditary non-polyposis colorectal cancer: The rise and fall of a confusing term

Table 1 Amsterdam I and II criteria and Bethesda (revised) guidelines

Term	Criteria	Reference
Amsterdam I1	Three 1st degree relatives with CRC	Vasen et al, 1991[13]
	Two generations affected
	One family member below age 50 yr
	Exclude familial adenomatous polyposis
Amsterdam II1	As for Amsterdam I except that CRC may be substituted by cancer of endometrium, small bowel, or pelviureter	Vasen et al, 1999[14]
Bethesda (revised)2		Umar et al, 2004[44]
1	CRC below age 50 yr
2	Multiple CRC or HNPCC-related cancers3
3	CRC with MSI-related histology4, < 60 yr
4	CRC or HNPCC-related cancer in at least one 1st degree relative, < 50 yr
5	CRC or HNPCC-related cancer in at least two 1st or 2nd degree relatives, any age

¹All criteria must be met;

²Any criterion (1-5) can be met;

³Includes cancer of endometrium, small bowel, pelviureter, biliary tract, stomach, ovary, pancreas, and brain (mainly glioblastoma multiforme);

⁴Tumor infiltrating lymphocytes, Crohn-like reaction, mucin/signet ring cell differentation, medullary growth pattern.