Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway

Figure 2 A: Time course of the GH (4 × 10^-9 mol/L) effect on CT (6 × 10^-8 mol/L)-induced short-circuit a current (Isc) increase in the absence or in the presence of L-NAME (2 × 10^-4 mol/L) in Caco-2 cells mounted in Ussing chambers. The arrows indicate the time of addition of each agent; B: Maximal Isc increase after CT addition, alone or in the presence of GH alone or in combination with L-NAME. A total abrogation of the antagonistic effect of GH on the CT-induced electrical response was observed in the presence of L-NAME. Data are mean ± SD of 6 different observations. ^aP < 0.05 CT alone vs GH + CT; ^cP < 0.05 GH + CT vs L-NAME + GH + CT.