CCR5Δ32 mutation does not influence the susceptibility to HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C

Table 5 Analysis of published data in chronic HCV patients genotyped for CCR5Δ32 mutation

Authors	Susceptibility	Histological Severity	Response to therapy	Genotype	Patients studied (n)
Ahlensteil G et al[27,28]	Yes	Not mentioned	Lower ETR1	Genotype 1 Genotype 2	59 3
				Genotype 3	9
				Genotype 4	3
				Undetermined	4
Glas J et al[29]	No	Not mentioned	No	Genotype 1/4	37
				Genotype 2/3	25
Goulding C et al[26]	2Spontaneous viral clearance	2Lower hepatic inflammation	Not mentioned	Genotype 1b	283
Hellier et al[13]	No	Decreased portal inflammation	No	Stratification not mentioned
Konishi et al[30]	No	No	No	Serotype 1	53
				Serotype 2	48
				Serotype 1 + 2	4
Mascheretti et al[31]	No	No	No	Genotype 1	358
				Genotype 2	14
				Genotype 3	79
				Genotype 4	14
Promrat et al[12]	No	No	No	Genotype 1	243
				Genotype 2	34
				Genotype 3	16
				Genotype 4	3
				Genotype 5	1
				Undetermined	42
Wald et al[32]	No	Significantly reduced	Not mentioned	Genotype 1	5
				Genotype 2	2
				Genotype 3	9
				Undetermined	31
Wasmuth et al[33]	No	No	No	Genotype 1	213
				Non-Genotype 1	117
Woitas et al[11]	Yes	Not mentioned	Not mentioned	Genotype 1	95
				Genotype 2	16
				Genotype 3	10
				Genotype 4	6
				Multiple genotype	5
				Undetermined	2
Present study Goyal et al	No	No	No	Genotype 1	16
				Genotype 2	1
				Genotype 3	161
				Genotype 4	4
				Undetermined	70

¹ All analysis mentioned w.r.t the CCR5Δ32 carriers.

² Heterozygotes for CCR5Δ32 mutation.