Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas

Figure 3 Role of Src in proliferation of tumour pancreatic acinar cells induced by the CCK2R. AR4-2J cells were stimulated with Gastrin (10 nmol/L) for the times indicated (A) or 15 s (B). A: Src activity was determined as described in Methods. Immunoprecipitated proteins were also analysed by western-blot using anti-Src antibodies. Results of autoradiography quantification are presented as mean ± SE. ^aP < 0.05 vs control. B: Serum-starved AR4-2J cells were treated with Gastrin for 48 h in the presence or absence of PP2 (10 μmol/L), and the proliferation determined as described in Methods. Data are presented as mean ± SE. ^cP < 0.001 vs control.