Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting

Table 1 Serum and urine biochemistries at 16 wk

	ALP	AST	ALT	Albumin	Testosterone	IGF-I	25-OH vit D	Osteocalcin	u-deoxypyridinoline
	(nkat)	(nkat)	(nkat)	(g/L)	ng/L	μg/L	ng/L	ng/L	(μmol/mol creatinine)
Control	2161 ± 369	1182 ± 277	940 ± 187	16.75 ± 0.71	5.41 ± 2.34	879.37 ± 245.51	25.63 ± 4.04	142.91 ± 32.9	48.8 ± 7.9
Control + rapamycin	2762 ± 389a	2022 ± 1152a	1155 ± 122a	15.78 ± 1.3	10.62 ± 9.1	616.02 ± 189.66	29.15 ± 8.00	147.43 ± 34.0	67.12 ± 13.6
PSS	7144 ± 2121b	2210 ± 741a	1538 ± 243b	15.25 ± 0.75a	3.55 ± 0.41a	290.28 ± 170.90a	23.89 ± 5.97	105.57 ± 38.3a	61.99 ± 18.7
PSS + rapamycin	8481 ± 3380b	3217 ± 1560a	1752 ± 549a	14.33 ± 1.22a	3.45 ± 0.74b	241.66 ± 80.58a	22.15 ± 5.07	119.61 ± 43.5	93.79 ± 30.6a

^aP < 0.05 vs Controls;

^bP < 0.001 vs Controls.