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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jul 21, 2006; 12(27): 4369-4376
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4369
Published online Jul 21, 2006. doi: 10.3748/wjg.v12.i27.4369
Table 4 Liver histological injury: Grading and staging (mean ± SD, n = 6)
| Liver histology | Chow | MCDD | MCDD | MCDD | MCDD | MCDD | MCDD | MCDD | MCDD | P |
| Only | Rosiglitzone | Metformin | M+R | Ezetimibe | Valsartan | R+M+V | R+M+V+E | |||
| Steatosis % | 0 | 91 ± 5 | 45 ± 5 | 74 ± 11 | 59 ± 11 | 77 ± 8 | 63% ± 8 | 51 ± 4 | 37 ± 15 | < 0.001 |
| Lobular inflammation | 0.5 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.5 ± 0.1 | 0.5 ± 0.1 | 0.6 | NS |
| Portal inflammation | None | None | None | None | None | None | None | None | None | NS |
| Fibrosis (> F1) | None | None | None | None | None | None | None | None | None | NS |
| # Rats w/MB | 0 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | NS |
| Ballooning | 0 | 2 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | NS |
| Pericellular fibrosis | 0 | 1 | 0 | 1 | 2 | 1 | 0 | 2 | 1 | NS |
- Citation: Assy N, Grozovski M, Bersudsky I, Szvalb S, Hussein O. Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2006; 12(27): 4369-4376
- URL: https://www.wjgnet.com/1007-9327/full/v12/i27/4369.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i27.4369