Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease

Table 2 Plasma cytokines, lipids, and biochemical parameters at the end of the study period (wk 15)

Parameters	MCDD	MCDD	MCDD	MCDD	MCDD	MCDD	MCDD	MCDD	P
	FL	Rosiglitazone	Metformin	M+R	Ezetimibe	Valsartan	R+M+V	R+M+V+E
% changes W/BW	+68	+12	+28	+20	+28	+16	+20	+28	< 0.001
ALT ( nkat/L)	800 ± 33	684 ± 16.5	650 ± 33	667 ± 16.5	684 ± 49.5	734 ± 49.5	684 ± 33	717 ± 33	NS
ALB (g/L)	33 ± 7	34 ± 8	33 ± 16	34 ± 15	33 ± 6	33 ± 8	38 ± 5	35 ± 2	NS
Cholesterol (mmol/L)	123 ± 13	148 ± 13	145 ± 17	106 ± 15	100 ± 7	121 ± 16	139 ± 10	97 ± 17	< 0.001
Triglyceride (mmol/L)	0.8 ± 0.1	0.33 ± 0.08	0.5 ± 0.1	0.4 ± 0.1	0.35 ± 0.07	0.4 ± 0.04	0.5 ± 0.06	0.43 ± 0.8	< 0.03
TNF-α (ng/mL)	17.8 ± 10.0	19 ± 15	10 ± 6	30 ± 26	12 ± 7	9 ± 7	10 ± 6	13 ± 12	< 0.01
HOMA-IR	18 ± 2	11 ± 1	12 ± 1	9 ± 0.5	13 ± 1	16 ± 2	9 ± 0.5	8 ± 1	< 0.001
% change	+157	-39	-33	-50	-28	-11	-50	-55