Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease

Table 1 Liver-related parameters, plasma biochemistry and cytokines in rats fed with methionine choline-deficient diet (MCDD) or choline-supplemented diet (Chow diet) (mean ± SD, n = 6)

Parameters	CL	FL	P values
	Chow diet	MCDD diet
Baseline rat mass (g )	227 ± 7	226 ± 6	0.5
Final rat mass (g )	406 ± 19	257 ± 12	0.03
Final liver mass (g )	10.2 ± 0.3	10.8 ± 0.8	0.4
Liver/body mass ratio	0.025 ± 0.003	0.042 ± 0.003	0.02
% change		68
Liver triglycerides (mol/g)	1.6 ± 0.3	21.8 ± 1.0	< 0.001
% change		1263
Liver cholesterol (mol/g)	0.5 ± 0.0	1.6 ± 0.2	< 0.03
% change		245
Serum HOMA-IRI	7 ± 0.3	18 ± 2.0	< 0.001
Liver tocopherol/MDA ratio	0.05	0.003	< 0.03
FL infiltration (%)	0	91 ± 5	< 0.001
ALT (nkat/L)	667 ± 83	800 ± 33	< 0.05

CL: Control liver; FL: Fatty liver; HOMA-IRI: Insulin resistance index; MDA: Malondialdehyde.