Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals

Table 1 Serum levels of TC, TG, HDL-C, LDL-C, FFA and the relative hepatic weight after treatment with osthole for 6 wk in alcohol-induced fatty liver rats (n = 10)

Group	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	FFA(μmol/L)	Relative hepatic weight (g/100 g)
Control	2.14 ± 0.28	0.40 ± 0.11	1.16 ± 0.16	0.80 ± 0.21	429.93 ± 90.28	2.36 ± 0.33
Model	2.52 ± 0.30a	0.51 ± 0.09a	0.96 ± 0.24a	1.32 ± 0.51b	535.04 ± 105.44a	2.82 ± 0.28b
Osthole 5 mg/kg	1.72 ± 0.18d	0.38 ± 0.08d	0.91 ± 0.30	0.64 ± 0.34d	477.37 ± 109.47	2.30 ± 0.14d
Osthole 10 mg/kg	1.69 ± 0.29d	0.36 ± 0.11d	1.02 ± 0.17	0.50 ± 0.17d	473.79 ± 196.55	2.30 ± 0.12d
Osthole 20 mg/kg	1.60 ± 0.36d	0.37 ± 0.06d	1.05 ± 0.15	0.43 ± 0.21d	487.59 ± 130.79	2.37 ± 0.19d
Lipanthyl 20 mg/kg	1.82 ± 0.28d	0.42 ± 0.09c	1.01 ± 0.20	0.62 ± 0.31d	654.74 ± 136.86c	3.45 ± 0.18d

^aP < 0.05,

^bP < 0.01 vs control animal.

^cP < 0.05,

^dP < 0.01 vs model animal.