Biochemical response to lamivudine treatment in HBeAg negative chronic hepatitis B patients in Iran

Table 1 Frequency of response and serum liver enzymes during 12-mo treatment of HBeAg negative patients with lamivudine (n=71)

	Baseline	3 mo		6 mo		12 mo
		Mean	Frequency of response	Mean	Frequency of response	Mean	Frequency of response
ALT (nkat/L)	1437 ± 205	1060 ± 122	65 (91.5%)	813 ± 160	61 (85.9%)	723 ± 92	38 (53.5%)
AST (nkat/L)	1060 ± 105	960 ± 77	68 (95.7%)	770 ± 88	63 (88.7%)	652 ± 75	36 (50.1%)

P = 0.002 for ALT between baseline and 12 mo treatment levels; P = 0.002 for AST between baseline and 12 mo treatment levels.