Antiviral treatment of hepatitis B virus-transgenic mice by a marine organism, Styela plicata

Figure 1 Rate of responses following therapy. Thirty-three percent (3 of 9) of HBV-Tg receiving lamivudine became completely negative for HBV-DNA compared with 22% (2 of 9) of HBV-Tg receiving the effective ingredient of Sp 8 wk after the start of therapy. They had the same cure rate (33%, 3 of 9) 12 wk after the start of therapy. But the inhibitory effect could not last long. A rebound phenomenon could be found 4 wk after withdrawal of medication. HBV-Tg receiving normal diet did not show such therapeutic response.