Antiviral treatment of hepatitis B virus-transgenic mice by a marine organism, Styela plicata

Table 1 Changes of HBsAg titers (mean ± SD)

Treatment group	OD values
	0 wk	4 wk	8 wk	12 wk	16 wk
Group 1 normal diet recipients (n = 9)	1.61 ± 0.01	1.61 ± 0.01	1.62 ± 0.02	1.62 ± 0.01	1.60 ± 0.02
Group 2 lamivudine recipients (n = 9)	1.59 ± 0.03	1.00 ± 0.21a,d	0.92 ± 0.15b,d	0.76 ± 0.08b,d	1.29 ± 0.11a,d
Group 3 Sp recipients (n = 9)	1.61 ± 0.02	1.32 ± 0.08a	1.01 ± 0.16b,d	0.82 ± 0.07b,d	1.05 ± 0.05b,d

^aP < 0.05, ^bP < 0.01 compared with T0 in one group; ^dP < 0.01 compared with group 1.