Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations

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Jun 28, 2006 (publication date) through Jul 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jun 28, 2006; 12(24): 3803-3809
Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3803

Table 1 Phenotypic expressions, tumor differentiation phenotype and genetic alterations in gastric adenoma and carcinoma n (%)

Phenotypic	Adenoma	Early	Advanced	Early and
expressions,tumor		carcinoma	carcinoma	advanced
differentiation				carcinoma
phenotype	(n = 48)	(n = 132)	(n = 39)	(n = 171)
&genetic
Alterations
HGM
Negative	43 (89.6)	49 (37.1)^d	15 (38.5)^d	64 (37.4)^d
Positive	5 (10.4)	83 (62.9)^d	24 (61.5)^d	107 (62.6)^d
MUC6
Negative	29 (60.4)	48 (36.4)^b	13 (33.3)^a	61 (35.7)^b
Positive	19 (39.6)	84 (63.6)^b	26 (66.7)^a	110 (64.3)^b
MUC2
Negative	6 (12.5)	35 (26.5)	15 (38.5)^a	50 (29.2)^a
Positive	42 (87.5)	97 (73.5)	24 (61.5)^a	121 (70.8)^a
CD10
Negative	16 (33.3)	100 (75.8)^d	28 (71.8)^c	128 (74.9)^d
Positive	32 (66.7)	32 (24.2)^d	11 (28.2)^c	43 (25.1)^d
Tumor differentiation phenotype
G-phenotype	2 (4.2)	30 (22.7)^d	10 (25.6)^d	40 (23.4)^d
GI-phenotype	19 (39.6)	82 (62.1)^d	24 (61.5)^d	106 (62.0)^d
I-phenotype	27 (56.3)	20 (15.2)^d	5 (12.8)^d	25 (14.6)^d
APC
Negative	29 (60.4)	110 (83.3)^b	37 (94.9)^c	147 (86.0)^d
Positive	19 (39.6)	22 (16.7)^b	2 (5.1)^c	24 (14.0)^d
p53
Negative	46 (95.8)	99 (75.0)^b	27 (69.2)^b	126 (73.7)^b
Positive	2 (4.2)	33 (25.0)^b	12 (30.8)^b	45 (26.3)^b
MSI status
MSS	40 (83.3)	107 (81.1)	34 (87.2)	141 (82.5)
MSI-L	4 (8.3)	16 (12.1)	2 (5.1)	18 (10.5)
MSI-H	4 (8.3)	9 (6.8)	3 (7.7)	12 (7.0)

HGM: Human gastric mucin, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001 vs adenoma.

Citation: Yamazaki K, Tajima Y, Makino R, Nishino N, Aoki S, Kato M, Sakamoto M, Morohara K, Kaetsu T, Kusano M. Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations. World J Gastroenterol 2006; 12(24): 3803-3809
URL: https://www.wjgnet.com/1007-9327/full/v12/i24/3803.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i24.3803