Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 24

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

All Articles published online

Item

Count

PDF

311

HTML

2459

Figures (1-5)

211

Tables (1-2)

199

Sum=3180

Jun 28, 2006 (publication date) through Nov 4, 2024

Times Cited of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Jun 28, 2006; 12(24): 3803-3809
Published online Jun 28, 2006. doi: 10.3748/wjg.v12.i24.3803

Table 1 Phenotypic expressions, tumor differentiation phenotype and genetic alterations in gastric adenoma and carcinoma n (%)

Phenotypic	Adenoma	Early	Advanced	Early and
expressions,tumor		carcinoma	carcinoma	advanced
differentiation				carcinoma
phenotype	(n = 48)	(n = 132)	(n = 39)	(n = 171)
&genetic
Alterations
HGM
Negative	43 (89.6)	49 (37.1)^d	15 (38.5)^d	64 (37.4)^d
Positive	5 (10.4)	83 (62.9)^d	24 (61.5)^d	107 (62.6)^d
MUC6
Negative	29 (60.4)	48 (36.4)^b	13 (33.3)^a	61 (35.7)^b
Positive	19 (39.6)	84 (63.6)^b	26 (66.7)^a	110 (64.3)^b
MUC2
Negative	6 (12.5)	35 (26.5)	15 (38.5)^a	50 (29.2)^a
Positive	42 (87.5)	97 (73.5)	24 (61.5)^a	121 (70.8)^a
CD10
Negative	16 (33.3)	100 (75.8)^d	28 (71.8)^c	128 (74.9)^d
Positive	32 (66.7)	32 (24.2)^d	11 (28.2)^c	43 (25.1)^d
Tumor differentiation phenotype
G-phenotype	2 (4.2)	30 (22.7)^d	10 (25.6)^d	40 (23.4)^d
GI-phenotype	19 (39.6)	82 (62.1)^d	24 (61.5)^d	106 (62.0)^d
I-phenotype	27 (56.3)	20 (15.2)^d	5 (12.8)^d	25 (14.6)^d
APC
Negative	29 (60.4)	110 (83.3)^b	37 (94.9)^c	147 (86.0)^d
Positive	19 (39.6)	22 (16.7)^b	2 (5.1)^c	24 (14.0)^d
p53
Negative	46 (95.8)	99 (75.0)^b	27 (69.2)^b	126 (73.7)^b
Positive	2 (4.2)	33 (25.0)^b	12 (30.8)^b	45 (26.3)^b
MSI status
MSS	40 (83.3)	107 (81.1)	34 (87.2)	141 (82.5)
MSI-L	4 (8.3)	16 (12.1)	2 (5.1)	18 (10.5)
MSI-H	4 (8.3)	9 (6.8)	3 (7.7)	12 (7.0)

HGM: Human gastric mucin, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001 vs adenoma.

Citation: Yamazaki K, Tajima Y, Makino R, Nishino N, Aoki S, Kato M, Sakamoto M, Morohara K, Kaetsu T, Kusano M. Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations. World J Gastroenterol 2006; 12(24): 3803-3809
URL: https://www.wjgnet.com/1007-9327/full/v12/i24/3803.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i24.3803