Pharmacogenetics in inflammatory bowel disease

Figure 2 The dotted arrows indicate inhibitory effects of MTX methotrexate. RFC1 reduced folate carrier 1; MTXglu methotrexate polyglutamate; AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide; DHF, dihydrofolate; THF, tetrahydrofolate; dhfr, dihydrofolate reductase; mthfr, methylene tetrahydrofolate reductase; 5,10-CH-THF, 5,10 methenyl THF; 5,10-CH2 THF, 5,10 methylene THF; 10-CHO THF, 10-formyl THF; Hcy, homocysteine; 5-CHO THF, 5-formyl THF; ms, methionine synthetase; Met, methionine; SAM, S-adenosyl-L-methionine; R, methyl acceptor; SAH, S-adenosyl–L-homocysteine.