Immunohistochemical expression of mismatch repair genes: A screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma

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Jun 21, 2006 (publication date) through Jul 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2006; 12(23): 3740-3745
Published online Jun 21, 2006. doi: 10.3748/wjg.v12.i23.3740

Table 2 Correlation between hMSH2 and hMLH1 immunohistochemical expression and microsatellite profile in ICC studied n(%)

MSstatus	Numberof cases	Pattern of nuclear expression/n (%)
MSstatus	Numberof cases	hMSH2+hMLH1-	hMSH2-hMLH1+	hMSH2+hMLH1+	hMSH2-hMLH1-
MSI	8	0 (0)	2 (25)	5 (62.5)	1 (12.5)
MSS	19	1 (5.3)	1 (5.3)	17 (89.5)	0 (0)
NP	2	0 (0)	0 (0)	2 (100)	0 (0)
Total	29	1 (3.4)	3 (10.3)	24 (82.8)	1 (3.4)

MSI: Microsatellite instability; MSS: Microsatellite stable; NP: MSI assessment was not performed.

Citation: Liengswangwong U, Karalak A, Morishita Y, Noguchi M, Khuhaprema T, Srivatanakul P, Miwa M. Immunohistochemical expression of mismatch repair genes: A screening tool for predicting mutator phenotype in liver fluke infection-associated intrahepatic cholangiocarcinoma. World J Gastroenterol 2006; 12(23): 3740-3745
URL: https://www.wjgnet.com/1007-9327/full/v12/i23/3740.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i23.3740