Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis

doi:10.3748/wjg.v12.i23.3636

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2006; 12(23): 3636-3644
Published online Jun 21, 2006. doi: 10.3748/wjg.v12.i23.3636

Table 2 Distribution of C3435T alleles and genotypes (cases and controls) in the existing literature

	C	T	CC	CT	TT
Glas, 2003
UC = 123¹	111 (45)	135 (55)	19 (15)	73 (60)	31 (25)
CD = 135	130 (48)	140 (52)	26 (19)	78 (58)	31 (23)
IBD = 258	241 (47)	275 (53)	45 (17)	151 (59)	62 (24)
HC = 265	272 (51)	258 (49)	70 (26)	132 (50)	63 (24)
Schwab, 2003	C	T	CC	CT	TT
UC^a = 149	129 (43)	169 (57)	26 (17)	77 (52)	46 (31)
HC = 149	154 (52)	144 (48)	39 (26)	76 (51)	34 (23)
CD = 126	134 (53)	118 (47)	33 (26)	68 (54)	25 (20)
HC = 126	128 (51)	124 (49)	35 (28)	58 (46)	33 (26)
IBD = 275	263 (48)	287 (52)	59 (21)	145 (53)	71 (26)
HC = 275	282 (51)	268 (49)	74 (27)	134 (49)	67 (24)
Ho, 2005	C	T	CC	CT	TT
UC^c = 335	280 (42)	390 (58)	61 (18)	158 (47)	116 (35)
CD = 268	252 (47)	284 (53)	56 (21)	140 (52)	72 (27)
IBD = 603	532 (44)	674 (56)	117 (19)	298 (50)	188 (31)
HC = 370	354 (48)	386 (52)	82 (22)	190 (51)	98 (27)
Palmieri, 2005	C	T	CC	CT	TT
UC = 468	488 (52)	448 (48)	124 (27)	240 (51)	104 (22)
CD = 478	503 (53)	453 (47)	125 (26)	253 (53)	100 (21)
IBD = 946	991 (52)	901 (48)	249 (26)	493 (52)	204 (22)
HC = 450	470 (52)	430 (48)	115 (26)	240 (53)	95 (21)
Potocnik, 2004	C	T	CC	CT	TT
UC = 144	134 (47)	154 (53)	-	-	-
CD = 163	161 (49)	165 (51)	-	-	-
IBD = 307	295 (48)	319 (52)
HC = 355	376 (53)	334 (47)	-	-	-
Urcelay, 2006
UC = 311	317 (51)	305 (49)	87 (28)	143 (46)	81 (26)
CD^b = 303¹	369 (61)	237 (39)	122 (40)	125 (41)	56 (19)
IBD = 614	686 (56)	542 (44)	209 (34)	268 (44)	137 (22)
HC = 324	344 (53)	304 (47)	97 (30)	150 (46)	77 (24)

UC = Ulcerative colitis, CD = Crohn’s disease, HC = healthy controls. ^aP = 0.045 (T vs C); P = 0.049 (TT vs CC). ^cP = 0.02 (T vs C); P = 0.04 (TT vs CC). ^bP = 0.006 (T vs C); P = 0.01 (TT vs CC). ¹ Subjects not in Hardy-Weinberg equilibrium.

Citation: Annese V, Valvano M, Palmieri O, Latiano A, Bossa F, Andriulli A. Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis. World J Gastroenterol 2006; 12(23): 3636-3644
URL: https://www.wjgnet.com/1007-9327/full/v12/i23/3636.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i23.3636