Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product

Table 3 Up-regulation of signal transduction-related genes in NIH-3T3 treated with O. viverrini, categorized in groups according to the response to the specific growth factor

Related growth factor	Gene name/production	Folding
PDGF/EGF
AW544655	Tyrosine kinase (v abl)	7.12
C80388	Protein kinase C (pkC)	4.23
AU042564	Casein kinase I-alpha isoform (csnk1α1)1	3.81
C87299	Casein kinase I-epsilon (csnk1ε)	2.88
AU046274	Ras-GTPase activating protein SH3-domain binding protein (c3bp-pending)	2.73
C87788	JAK1 protein tyrosine kinase	2.56
AU017366	H ras	2.26
AW552623	N ras	2.01
PDGF
AW537708	PDGF receptor, alpha-polypeptide (pdgfrα)	2.64
EGF
C88280	Epidermal growth factor receptor pathway substrate (eps 8)	2.32
TGF- β
AW546174	Transforming growth factor beta-1-induced transcript 4 (tgf β 1i4)	8.24
AU016757	c myc	3.70
C79202	Serine/threonine kinase receptor-associated protein (strap)	3.40

¹Represents human gene.