Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product

Table 2 Proliferation-related genes with 2-fold and more¹ up-regulation in fibroblast cell proliferation activated by O. viverrini ES product compared to the negative control (not exhaustive)

A Energy and metabolism	Glyceraldehyde-3-phosphate dehydrogenase (gapd), cyto-chrome C oxidase, alpha-enolase, ATP synthase beta sub-unit2, thioredoxin, aldehyde dehydrogenase
B Signal transduction	Transforming growth factor beta-1-induced transcript 4 (tgfβ 1i4), tyrosine kinase (abl 1), interleukin 1 receptor-associated kinase, MAP kinase phosphatase (mkp 6), colony stimulating factor 3 receptor, protein kinase C, Janus kinase 2 (Jak 2), casein kinase I alpha (csnk 1a1), c-myc
C Protein synthesis and translation	Polyubiquitin C (Ubc) gene, ribosomal protein S27a2, ribosomal protein L27, elongation factor Tu, RNA polymerase 1-2, translation initiation factor 4 gamma2
D Matrix and structural protein	Lysophospholipase 1 (lypla 1)
E Transcription control	Transformation/transcription domain-associated protein (trrap)2, telomeric repeat binding factor 1 (terf 1), transcription factor EB (tcfeb), DEAD-box RNA helicase (ddx 21)2
F Cell cycle	Kinesin family member 3a (kif 3a), mitotic kinesin-linked protein 12, cyclin-dependent kinase 4 (cdk 4), cdk 5, cyclin B1
G DNA replication	RPII215 polymerase II large sub-unit, topoisomerase II alpha, DNA primase p58 subunit (prim 2), ribonucleotide reductase

¹Sequence in each group is ordered from high to low expression increases;

²represents human gene.