Synchronous and metachronous occurrence of gastric adenocarcinoma and gastric lymphoma: A review of the literature

Table 2 Metachronous cases reported in the literature

Reference	Age/sex	Lymphoma type	Lymphoma therapy	Interval	Adenocarcinoma therapy
McNeer[32]	27/f	Reticulum cell sarcoma	S. gastrectomy; radiotherapy for local recurrence	6.5 yr	T. gastrectomy
Fleischer and Walker[33]	61/m	Lymphosarcoma	S. gastrectomy; 4000 cGy	5 yr	Supportive treatment
Bockus[34]	49/m	Lymphosarcoma	Radiotherapy	3.5 yr	T. gastrectomy
Komarov[35]	40/m	Round cell sarcoma	S. gastrectomy	19 yr	NM
Morgenstern[36]	46/f	Reticulum cell sarcoma	S. gastrectomy	25 yr	Resection
Ettinger and Carter[37]	55/m	Lymphosarcoma	S. gastrectomy; 2000-2600 cGy	16 yr	Palliative surgery
Shani[38]	47/m	Reticulum cell sarcoma	S. gastrectomy	31 yr	Resection
	29/m	Diffuse, poorly differentiated lymphocytic	S. gastrectomy; orthovoltage for whole abdomen (6 d)	34 yr	Exploration
	51/f	Diffuse, mixed lymphocytic histiocytic	S. gastrectomy; 1800 cGy X-R + 2000 cGy Co 60. 12030 cGy for recurrence (16 yr later)	16 yr	Exploration
	48/m	Diffuse, poorly differentiated lymphocytic	S. gastrectomy; 3000 cGy.	10 yr	Exploration; combined chemotherapy
Sellin[39]	45/m	Diffuse, large cleaved cell	2300 cGy; S. gastrectomy; 4000 cGy (4 yr later)	13 yr	Total gastrectomy
Brumback[40]	8/m	Diffuse undifferentiated (small noncleaved)	S. gastrectomy; cyclophosphamide, vincristine, prednisolone for 1 mo; 4075 cGy; 6-mercaptopurine, vincristine, prednisolone, methotrexate for 3 yr	6 yr	Gastrojejunal bypass; 5-FU, doxorubicine, mitomycin chemotherapy
	15/m	Hodgkin’s disease, nodular sclerosis type	3500 cGy to upper abdomen; 2000 cGy to left axillary-cervical-supraclavicular; cyclophosphamide, vincristine, procarbazine, prednisolone, adriamycin for 2 yr	10 yr	NM
	24/f	Reticulum cell sarcoma	S. gastrectomy; 4000 cGy	15 yr	No treatment
	60/m	Diffuse large cell	S. gastrectomy; cyclophosphamide, vincristine, prednisolone, doxorubicin chemotherapy	4 yr	T. gastrectomy and S. esophagectomy
	56/m	Well differentiated lymphocytic	S. gastrectomy; 3700 cGy; oral cyclophosphamide chemotherapy	12 yr	T. gastrectomy
Zorlu[42]	43/m	Diffuse, large cleaved cell	S. gastrectomy; cyclophosphamide, vincristine, prednisolone ( 2 courses); 4500 cGy; cyclophosphamide, vincristine, prednisolone (4 courses)	8 yr	Near total gastrectomy; 5-FU, mitomycin
	35/f	Diffuse, large cleaved cell	S. gastrectomy; 4000 cGy; cyclophosphamide, vincristine, prednisolone (6 courses)	8 yr	T. gastrectomy
Nakamura[10]	69/f	Immunoblastic	NM	7 yr	S.gastrectomy
	82/f	MALT, HG	NM	13 mo	Endoscopic mucosal resection
Zauber[43]	78/f	Large cleaved cell	S. gastrectomy; 4500 cGy; i.v. cyclophosphamide chemotherapy (9 courses)	4 yr	T. gastrectomy
Montalban[26]	42/m	MALT	Cyclophosphamide, doxorubicin, vincristine, prednisone	108 mo	NM
Hasegawa[44]	72/f	MALT	Antibiotic therapy for H pylori	6 mo	S. gastrectomy
Morgner[45]	74/m	MALT, LG	Antibiotic therapy for H pylori	4 yr	Endoscopic mucosal resection
	70/m	MALT, LG	Antibiotic therapy for H pylori	5 yr	Endoscopic mucosal resection and argon plasma coagulation
	77/f	MALT, LG	Antibiotic therapy for H pylori	4 yr	Endoscopic mucosal resection
Ghosdal[46]	32/m	MALT, LG	S. gastrectomy; Antibiotic therapy for H pylori (for 2 wk);	15 mo	No treatment
Raderer[47]	67/f	MALT	Antibiotic therapy for H pylori ( for 9 mo)	9 mo	S. gastrectomy
	61/f	MALT	Antibiotic therapy for H pylori ( for 14 mo); 2CdA chemotherapy (4 courses)	27 mo	S. gastrectomy

m: male, f: female, NM: not mentioned, MALT: mucosa-associated lymphoid tissue, HG: high grade, LG: low grade, S. gastrectomy: subtotal gastrectomy, T. gastrectomy: total gastrectomy,

¹Only 2 cases reported by Nakamura et al were diagnosed as lymphoma after the treatment of gastric adenocarcinoma.