Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice

Figure 1 GalN/LPS induced changes in mice. A: Survival rate (n = 10); B: Plasma ALT (mean ± SE, n = 6). ^aP < 0.05, ^bP < 0.01, vs WT; C: Histology of the liver. Massive liver injury in adiponectin-/- mice. (Hematoxylin-eosin × 100); D: Large numbers of apoptotic hepatocytes in adiponectin-/- mice (TUNEL × 100). Scale bar = 400 μm. ^aP < 0.05, vs WT mice.