Expression of Interleukin-11 and Interleukin-11 receptor &alpha; in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors

doi:10.3748/wjg.v12.i2.317

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2006; 12(2): 317-321
Published online Jan 14, 2006. doi: 10.3748/wjg.v12.i2.317

Table 1 Expression of IL-11 and IL-11Rα in colorectal carcinoma, (%)

	n	IL-11			IL-11Rα
	n	-	+	++	-	+	++
Normal mucosa		¹P = 0.001883, vs carcinoma			¹P = 0.00196, vs carcinoma
	10	5 (50.0)	3 (30.0)	2 (20.0)	6 (60.0)	4 (40.0)	0 (0.0)
Adenoma		¹P = 0.023291, vs carcinoma			¹P = 0.000833, vs carcinoma
	11	5 (45.5)	2 (18.2)	4 (36.4)	7 (63.6)	4 (36.4)	0 (0.0)
Total carcinoma	115	15 (13.0)	26 (22.6)	74 (64.3)	28 (24.3)	31 (27.0)	56 (48.7)
Histological differentiation		NS			¹P = 0.033503
Wel	57	8 (14.0)	15 (26.3)	34 (59.6)	17 (29.8)	16 (28.1)	24 (42.1)
Mod	46	5 (10.9)	8 (17.4)	33 (71.7)	6 (13.0)	14 (30.4)	26 (56.5)
Por	5	0 (0.0)	1 (20.0)	4 (80.0)	1 (20.0)	0 (0.0)	4 (80.0)
Muc	7	2 (28.6)	2 (28.6)	3 (42.9)	4 (57.1)	1 (14.3)	2 (28.6)
Depth of tumor invasions		NS			¹P = 0.006395
Tis	24	4 (16.7)	6 (25.0)	14 (58.3)	8 (33.3)	10 (41.7)	6 (25.0)
T1	11	1 (9.1)	5 (45.5)	5 (45.5)	6 (54.5)	2 (18.2)	3 (27.3)
T2	10	1 (10.0)	1 (10.0)	8 (80.0)	2 (20.0)	3 (30.0)	5 (50.0)
T3	48	7 (14.6)	9 (18.8)	32 (66.7)	8 (16.7)	10 (20.8)	30 (62.5)
T4	22	2 (9.1)	5 (22.7)	15 (68.2)	4 (18.2)	6 (27.3)	12 (54.5)
Dukes’ classification		NS			¹P = 0.015648
A	44	6 (13.6)	13 (29.5)	25 (56.8)	16 (36.4)	15 (34.1)	13 (29.5)
B	35	4 (11.4)	6 (17.1)	25 (71.4)	4 (11.4)	8 (22.9)	23 (65.7)
C	32	4 (12.5)	6 (18.8)	22 (68.8)	7 (21.9)	7 (21.9)	18 (56.3)
D	4	1 (25.0)	1 (25.0)	2 (50.0)	1 (25.0)	1 (25.0)	2 (50.0)
Lymphatic invasion		NS			¹P = 0.003865
Present	76	11 (14.5)	14 (18.4)	51 (67.1)	15 (19.7)	16 (21.1)	45 (59.2)
Absent	39	4 (10.3)	12 (30.8)	23 (59.0)	13 (33.3)	15 (38.5)	11 (28.2)
Venous invasion		NS			NS
Present	44	5 (11.4)	10 (22.7)	29 (65.9)	8 (18.2)	11 (25.0)	25 (56.8)
Absent	71	10 (14.1)	16 (22.5)	45 (63.4)	20 (28.2)	20 (28.2)	31 (43.7)
Lymphnode metastasis		NS			NS
Present	35	5 (14.3)	6 (17.1)	24 (68.6)	8 (22.9)	7 (20.0)	20 (57.1)
Absent	80	10(12.5)	20 (25.0)	50 (62.5)	20 (25.0)	24 (30.0)	36 (45.0)

NS: Not significant,

¹statistical analyses are performed by Spearman’s correlation coefficient by rank test or Mann-Whitney’s U test methods.

Citation: Yamazumi K, Nakayama T, Kusaba T, Wen CY, Yoshizaki A, Yakata Y, Nagayasu T, Sekine I. Expression of Interleukin-11 and Interleukin-11 receptor α in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors. World J Gastroenterol 2006; 12(2): 317-321
URL: https://www.wjgnet.com/1007-9327/full/v12/i2/317.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i2.317