Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats

Table 4 AST, ALT, LDH, total and direct bilirubin levels in different groups after treatment (mean ± SE)

Group	AST(U/L)	ALT(U/L)	LDH(U/L)	Total bilirubin(mg/dL)	Direct bilirubin(mg/dL)
Control	186.85 ± 19.5	53.71 ± 2.39	4088.43 ± 510.5	0.02 ± 0.02	0.01 ± 0.01
Caerulein	259.57 ± 18.60a	68.14 ± 4.04a	7631.14 ± 281.3c	6.88 ± 0.12c	3.06 ± 0.09c
Caerulein + mel	193.28 ± 26.64	47.71 ± 6.98	5065.71 ± 508.10	0.04 ± 0.01g	0.00 ± 0.01g
Caerulein + antioxidant mixture	274.71 ± 17.16	70.14 ± 4.84e	6592.71 ± 1065.41	0.05 ± 0.02g	0.04 ± 0.02g

^aP < 0.05 vs control; ^cP < 0.005 vs control; ^eP < 0.05 vs caerulein+mel; ^gP < 0.005 vs caerulein.