Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

Table 4 Hepatic prostaglandin E2 (PGE2) generation, myeloperoxidase (MPO) activity and hydroxyproline (HP) content in different groups of rats (mean±SE)

Subgroup	n	PGE2 generation(ng/g liver)	HP content(ng/g liver)	MPO activity(units/g liver)
Sham only	5	14.8 ± 9.9	8.59 ± 0.551	0.45 ± 0.14
Sham and phlebotomy later	4	14.7 ± 5.2	8.11 ± 1.03	0.31 ± 0.12
Phlebotomy and sham later	6	6.9 ± 3.2	8.02 ± 1.00	0.18 ± 0.05
BDL only	9	8.5 ± 4.5	11.00 ± 0.97	0.59 ± 0.21
BDL and phlebotomy later	8	3.9 ± 2.11	9.80 ± 1.68	0.52 ± 0.10
Phlebotomy and BDL later	8	3.4 ± 2.31	11.90 ± 1.40	0.27 ± 0.171

¹P ≤ 0.018 vs BDL only.