Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

Table 3 Histological grading and staging and bile duct proliferation score in different groups of rats (mean±SE)

Subgroup	n	Periportal necrosis	Portal inflammation	Lobular necrosis	Fibrosis	Bile duct proliferation
Sham only	5	0.00 ± 0.00	0.40 ± 0.55	1.00 ± 1.22	0.00 ± 0.001	0.00 ± 0.001
Sham and phlebotomy later	4	0.00 ± 0.00	1.25 ± 1.26	0.25 ± 0.50	0.00 ± 0.00	0.00 ± 0.00
Phlebotomy and sham later	6	0.00 ± 0.00	1.00 ± 0.00	0.50 ± 0.55	0.67 ± 0.52	0.00 ± 0.00
BDL only	9	0.89 ± 1.27	1.33 ± 1.00	2.11 ± 1.83	2.89 ± 0.78	2.67 ± 0.50
BDL and phlebotomy later	8	0.13 ± 0.35	1.00 ± 0.00	3.00 ± 1.85	2.75 ± 0.71	2.88 ± 0.35
Phlebotomy and BDL later	8	2.17 ± 1.33	2.67 ± 0.82	4.00 ± 0.00	3.33 ± 0.52	2.83 ± 0.41

¹P ≤ 0.003 vs BDL only.