Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

Table 2 Liver function tests and enzymes in different groups of rats (mean±SE)

Subgroup	n	GGT(IU/L)	ALK- P(IU/L)	Bilirubin(µmol/L)	GPT(IU/L)	Albumin(G/L)
Sham only	5	7.0 ± 2.01	254 ± 321	4.6 ± 1.81	53 ± 112	28.0 ± 1.11
Sham and phlebotomy later	4	6.0 ± 1.4	305 ± 58	4.0 ± 0.8	66 ± 8	29.2 ± 2.2
Phlebotomy and sham later	6	14.3 ± 10.3	305 ± 61	41.7 ± 39.0	55 ± 20	28.4 ± 2.3
BDL only	9	74.0 ± 63.4	580 ± 174	106.0 ± 57.0	115 ± 50	24.3 ± 2.2
BDL and phlebotomy later	8	65.9 ± 17.9	578 ± 75	104.0 ± 16.2	125 ± 22	29.0 ± 2.01
Phlebotomy and BDL later	8	64.3 ± 17.6	665 ± 166	109.0 ± 39.0	144 ± 40	23.7 ± 2.1

¹P ≤ 0.007,

²P ≤ 0.02 vs BDL only GGT = Gamma-glutamyl transpeptidase, ALK-P = Alkaline phosphatase, GPT = Alanine aminotransferase. No difference in the levels of serum parameters like calcium, phosphor, urea, creatinine and electrolytes were found between the different groups (data not shown).