Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins

Figure 4 Effects of lafutidine and capsaicin on mucosal PGE₂ contents in rat stomachs. The animals were given lafutidine (10 mg/kg) or capsaicin (10 mg/kg) po and killed 1 h later. Indomethacin (5 mg/kg) was administered sc 30 min before capsaicin or lafutidine. Gastric mucosal PGE₂ content was determined by EIA. Data are presented as the mean ± SE from 5 rats. ^aP < 0.05 vs control.