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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. May 7, 2006; 12(17): 2742-2748
Published online May 7, 2006. doi: 10.3748/wjg.v12.i17.2742
Published online May 7, 2006. doi: 10.3748/wjg.v12.i17.2742
Table 2 ANOVA for assessment of the drugs, subjects and period effects, and 90% CI for the test/reference ratio of Cmax, AUC(0-t) and AUC(0-∞), using logarithmic transformed data, after administration of two compound ranitidine preparations (equivalent to 200 mg of ranitidine and 220 mg of bismuth) to 20 Chinese volunteers (ɑ= 0.05).
Component | Parameters | ANOVA (P-value) | 90% CI (%) | ||
Variation source | |||||
Drug | Subjects | Period | |||
Ranitidine | Cmax | 0.9191 | 0.0686 | 0.7679 | 86.7-113.6 |
AUC(0-t) | 0.3917 | 0.0153 | 0.8366 | 96.0-113.4 | |
AUC(0-∞) | 0.4733 | 0.02118 | 0.9064 | 95.3-112.5 | |
Bismuth | Cmax | 0.65695 | 0.51515 | 0.39551 | 89.8-120.0 |
AUC(0-t) | 0.66066 | 0.11347 | 0.71245 | 88.1-124.0 | |
AUC(0-∞) | 0.75149 | 0.15804 | 0.87169 | 85.3-111.5 |
- Citation: Zhou Q, Ruan ZR, Yuan H, Jiang B, Xu DH. Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations. World J Gastroenterol 2006; 12(17): 2742-2748
- URL: https://www.wjgnet.com/1007-9327/full/v12/i17/2742.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i17.2742