Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations

Table 1 Pharmacokinetic parameters of ranitidine and bismuth after a single oral dose of compound ranitidine preparation (equivalent to 200 mg of ranitidine and 220 mg of bismuth) in 20 Chinese volunteers (mean ± SD)

Component	Parameters	Test	Reference
Ranitidine	Tmax (h)	2.3 ± 0.9	2.1 ± 0.9
	Cmax (mg/L)	0.67 ± 0.21	0.68 ± 0.22
	T1/2 (h)	2.8 ± 0.3	3.1 ± 0.4
	AUC(0-t) (mg/L per hour)	3.1 ± 0.6	3.0 ± 0.7
	AUC(0-∞) (mg/L per hour)	3.3 ± 0.6	3.2 ± 0.8
Bismuth	Tmax (h)	0.50 ± 0.20	0.50 ± 0.20
	Cmax (μg/L)	11.80 ± 7.36	11.40 ± 6.55
	T1/2 (h)	10.2 ± 2.3	13.0 ± 6.9
	AUC(0-t) (μg/L per hour)	46.65 ± 16.97	47.03 ± 21.49
	AUC(0-∞) (μg/L per hour)	55.38 ± 21.27	57.81 ± 23.31