Copyright
©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 28, 2006; 12(16): 2593-2600
Published online Apr 28, 2006. doi: 10.3748/wjg.v12.i16.2593
Published online Apr 28, 2006. doi: 10.3748/wjg.v12.i16.2593
Table 2 Influence of various systems / mechanisms on insulin-induced acceleration of small intestinal transit in normal mice
PretreatmentAgent/vehicle(mg/kg iv)1 | TreatmentInsulin(2 µU/kg sc)2 | % SITmean ± SE | %Acceleration | %Inhibition |
Vehicle | Vehicle | 55.10 ± 1.46 | -- | -- |
Vehicle | Insulin | 74.76 ± 1.40a | 35.683 | -- |
Atropine (1) | Vehicle | 29.19 ± 3.28a | -- | 47.023 |
Atropine (1) | Insulin | 37.32 ± 3.58b | -- | 50.084 |
Clonidine (0.1) | Vehicle | 15.50 ± 1.46a | -- | 71.863 |
Clonidine (0.1) | Insulin | 27.71 ± 4.78b | -- | 62.934 |
Ondansetron (1) | Vehicle | 51.69 ± 1.13 | -- | 6.183 |
Ondansetron (1) | Insulin | 63.84 ± 5.88 | -- | 14.604 |
Naloxone (5) | Vehicle | 32.39 ± 2.56a | -- | 41.213 |
Naloxone (5) | Insulin | 53.90 ± 2.95b | -- | 27.904 |
Verapamil (8) | Vehicle | 40.72 ± 1.72a | -- | 26.093 |
Verapamil (8) | Insulin | 48.61 ± 3.27b | -- | 34.974 |
Glibenclamide(10) | Vehicle | 79.23 ± 1.52a | 43.793 | -- |
Glibenclamide(10) | Insulin | 88.88 ± 3.52 | 18.884 | -- |
Glibenclamide(10) | Insulin | 88.88 ± 3.52 | 61.303 | -- |
- Citation: Peddyreddy MKR, Dkhar SA, Ramaswamy S, Naveen AT, Shewade DG. An inherent acceleratory effect of insulin on small intestinal transit and its pharmacological characterization in normal mice. World J Gastroenterol 2006; 12(16): 2593-2600
- URL: https://www.wjgnet.com/1007-9327/full/v12/i16/2593.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i16.2593